Wu Guang
2007
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To design and synthesize 5′-deoxy-5-fluorocytidine derivatives as antitumor drugs.Methods A series of 5′-deoxy-5-fluorocytidine alkylamine,alkoxyl and amidine derivatives were synthesized by displacement of triazole group at C-4 of 1-(2′,3′-O-diacetyl-5′-deoxy-β-D-ribofuranosyl)-4-(1,2,4-triazol-1-yl)-5-fluoropyrimidin-2-(1H)-one,which was obtained conveniently by condensation between 2′,3′-O-diacetyl-5′-deoxy-5-fluorocytidine and 1,2,4-triazole in the presence of POCl3.Results Fifteen new compounds were prepared,all of the products were confirmed by 1H-NMR,FAB-MS,and elemental analysis.Conclusion Antitumor activity results indicated that some of the title compounds had similar inhibitory effect on the lung cancer cell,breast cancer cell,liver cancer cell,and colon cancer cell as capecitabine did.