Qi Hao-fei
2011
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
A key intermediate,N-【{3-[3-fluoro-4-(1-piperazinyl)phenyl]-4,5-dihydro-5-isoxazolyl}methyl】acetamide(4),was prepared from 3,4-difluorine-benzaldehyde by a four-reaction.Six novel isoxazoline compounds were synthesized by nucleophilic substitution of 4 with substitute-benzene sulfonyl chloride.The structures were characterized by 1H NMR and MS.The preliminary biological activities test showed that some of them exhibited better anti-tumor activities.