Cai Zhi-qian
2015
Citations
0
Influential Citations
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Quality indicators
Journal
Chinese Journal of Synthetic Chemistry
Abstract
Six novel quinazoline derivatives( 5a ~ 5f) were synthesized by a four-step reaction of reduction,substitution,Suzuki and addition from substituted 4-[( 4-nitro phenoxy) methyl]piperidine.The structures were characterized by1 H NMR and ESI-MS. The in vitro antitumor activities of 5a ~ 5f against HUVEC,A-549,MCF-7 and HL-60 were investgated by MTT method. The results showed that cyclopropy【4-【【4-【【6-【5-{ [( 2-methylsulfonylethyl) amino]methyl } furan-2-yl 】quinazolin-4-yl】amino】phenoxy】methyl】piperidin-1-yl】methanone( 5b) exhibited better antitumor activities than Lapatinib. The IC50 of 5b was 0. 55 μg·m L- 1,0. 18 μg·m L- 1,0. 27 μg·m L- 1and 5. 24 μg·m L- 1,respectively.