Wang Yuan-chao
2011
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Journal
The Chemical Engineer
Abstract
(S/R)-methyl 2-(5-fluorouracil-1-ylaceto)amino-3-phenylpropanoate was synthesized by L/D phenylalanine methyl ester with EDCI/HOBt as a coupling reagent,and 5-flurouracil-1-yl acetic acid as an intermediate.The two compounds were characterized by 1H NMR,13C NMR,IR,MS,and the specific rotation etc.The antitumor activities tests indicated that the compounds have some anti-tumor effects in vitro.