Z. Xin
2012
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Journal of Harbin Medical University
Abstract
Objective To synthesize 5-(4-chlorophenyl)-N,N-dimethyl-7-(trifluoromethyl) pyrazolo pyrimidine-3-carboxamide,and to assay its antitumor activities.Methods Based on the general structure of pyrazolo pyrimidine processing antitumor activity,5-(4-chlorophenyl)-N,N-dimethyl-7-(trifluoromethyl) pyrazolo pyrimidine-3-carboxamide was designed,and the target compound was synthesized via a 4-step procedure starting from Ethyl(ethoxymethylene) cyanoacetate and 4-Chloroacetophenone.With CTX as a positive control,the target compound for anti-tumor activity was measured in vivo.Results Three novel compounds were synthesized,and their structures were confirmed by IR and 1 H-NMR.Conclusion Compound 7 displays good antitumor activities.