M. El-Enany, M. Kamel, Omneya M. Khalil
Sep 30, 2011
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14
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Journal
European Journal of Chemistry
Abstract
A novel series of pyrazolo[1,5- a ]pyrimidine-3-carbonitriles substituted with 7-amino, 7-substituted amino and 5-substituted amino groups was synthesized. Some of the newly synthesized compounds were tested in vitro on human colon tumor cell line (HCT116). Compound 14a displayed the highest activity among the tested compounds with IC 50 that equals to 0.0020 μM.