G. L. Arutyunyan, A. A. Chachoyan, Ts. E. Agadzhanyan
Dec 1, 1996
Citations
0
Influential Citations
12
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
Previously we reported that interactions of 1,5-dimethyl-9oxo-3,7-diazabicyclo[3.3.1]nonane with cyclopentanone and cyclohexanone led to the formation of 5,7-dimethyl-6-oxospiro(l,3-diazaadamantane-2, l'-cyclopentane) (I) and 5,7-dimethyl-6-oxospiro( 1,3-diazaadamantane-2, l'-cyclohexane) (II) [1]. In continuation of the work [1 ] we have studied the interaction of 3,7-diazabicyclo[3.3.1]nonane with ketones of heterocyclic (2,2-dimethyltetrahydropyran-4-one [2], 2,2-dimethyltetrahydrothiopyran-4-one [3], N-benzylpiperidin-4one [4]) and polyhedral (adamantan-2-one [5]) series. As a result, we have synthesized new heterocyclic systems: a series of spiroheterocyclic ( I I I -V) and one spiropolyhedral (VI) derivatives of 1,3-diazaadamantane. In order to establish a relationship between chemical structure and biological activity of the new compounds, we have studied the antitumor properties of the new spirocyclic derivatives of 1,3-diazaadamantane (III VI) and of the previously synthesized compounds I and II.