Liao Wen-j
2015
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Chinese Journal of Synthetic Chemistry
Abstract
Six novel diazole 4-aminoquinazoline derivatives(3a ~ 3f) were synthesized by substitution reaction of N-(3-chloro-4-fluorophenyl)-[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amine and a series of substituted diazoles.The structures were characterized by1 H NMR,13 C NMR,IR and elemental analysis.Anti-tumour activities of 3a ~ 3f were investigated against PC-3 and Bcap-37 cell by MTT method.The results showed that(3-chloro-4-fluorophenyl)-【6-methoxy-7-{ 3-[5-(4-nitrobenzyl)-[1,3,4]thiadiazol-2-ylsulfanyl]-propoxy}-quinazolin-4-yl】amine and 7-【{3-[5-(4-chlorobenzyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-propoxy}-6-methoxyquinazolin-4-yl】-(3-chloro-4-fluorophenyl)-amine exhibited high inhibitory activities in vitro against PC-3 cell.Inhibition were 66.8% and72.2% at 10 μmol·L-1,respectively.