M. S. Salga, I. Sada, A. Mustapha
Feb 11, 2017
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Quality indicators
Journal
Journal Of Chemical Society Of Nigeria
Abstract
The Schiff base ligand (N’,E,N”E)-N’,N”-bis(1-pyridin-2-yl)ethylidene)cyclohexane-1,2-diamine and its Zinc complex was synthesized and characterized by CHN, FTIR, 1 H-NMR and UV-visible analysis whereby the structure of the Schiff base was confirmed by X-ray diffraction analysis, showing that the cyclohexane ring adopts a chair conformation with the two imine groups linked at equatorial positions. The two halves of the molecule are related by a crystallographic two fold rotation axis. The dihedral angle between the pyridine rings is 75.73 (3) o . A zinc complex of this ligand was prepared through direct reaction at room temperature. All effort to produce high quality crystals was unsuccessful; however, it shows consistent spectral results with the ligand except in the position of azomethine which may be due to complexation. Both the ligand and its zinc complex were screened and evaluated for anti-ulcer activity against ethanol induced gastric ulceration. The result has shown that, administration of the ligand at the dose of 50 mg/kg markedly decreases the ulcer incidence more than both the Zn-complex and the referenced drug (Omeprazole). This is evident from the manifestation of the flattening of gastric mucosa and the complete absence of lesions in the gastric wall of the ligand treated group and appearance of some few lesions in the zinc and omeprazole groups. Keywords: Synthesis, Characterization, Crystal structure, Anti-ulcer study