B. B. Subudhi, P. Panda, D. Bhatta
May 1, 2009
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0
Influential Citations
13
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Quality indicators
Journal
ChemInform
Abstract
3,5-Diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(substituted)-pyridines 1a-e are prepared following Hantzsch pyridine synthesis by condensation of ethyl acetoacetate with different aromatic aldehydes in presence of ammonium hydroxide. Compounds 1a-e on reaction with paraformaldehyde and sulfanilamide yielded 3,5-diethoxycarbonyl-1-[(4'-sulfamoyl-1'-amino methyl) phenyl]-1,4-dihydro-2,6-dimethyl-4-(substituted)-pyridines 2a-e. The antiulcer activities have been performed by estimating volume of gastric acid, pH, free acidity, total acidity and ulcer index. The antiulccr activity of 1,4-dihydropyridines is enhanced significantly on conjunction with sulfanilamide. Substitution of methoxy group increased the antiulcer potential of the compounds.