T. Ueda, S. Toyoshima, T. Tsuji
Jun 1, 1964
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Journal
The Keio journal of medicine
Abstract
1) Guanidine nitrate (G.N.) was found to inhibit the multiplication of the K-2211 strain of common cold virus. Based on this finding, the method of screening for the K-2211 strain virus was arranged.2) According to the above screening method, 1-(p-substituted phenyl)-3-dimethylamino-1-propanols were screened as to their antiviral activities for the K-2211 strain virus. 1-Biphenylyl-3-dimethylamino-l-propanol was found to possess the almost equal activity with that of G.N.3) The relationship between the antiviral properties and the chemical constitution of 1-(p-substituted phenyl)-3-dimethylamino-l-propanols was dis-cussed.