S. Bhat
Aug 9, 1994
Citations
0
Influential Citations
2
Citations
Journal
ChemInform
Abstract
Reaction of 2,4-Dimethoxy-6-methylpyrimidine ( I ) with allyl bromide or benzyl bromide afforded 1-substituted 4-methoxy-6-methyl-2(1 H )-pyrimidinone intermediates III , X . Oxidation of the compound III afforded racemic cis diol VI . O -Demethylation and nucleophilic displacement of the intermediates III , VI and X gave 1-substituted 6-methyluracils IV , VII , IX and 1-substituted 4-alkylamino-6-methyl-2(1 H )-pyrimidinones V , VIII , XII in good yields. The compounds II - XII were evaluated against Ranikhet disease virus (RDV); compounds Vb , VII , X , XIIb - XIId showed 100, 43, 44, 75, 72 and 100% inhibition, respectively.