V. K. Pandey, V. Singh, Meenal Tandon
Aug 1, 2004
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0
Influential Citations
3
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Journal
ChemInform
Abstract
p-Phenylacetophenone 1 is synthesized by Friedel-Crafts acylation of diphenyl. Bromination of 1 in gl. acetic acid affords p-phenyl phenacyl bromide 2, which on reaction with 7-hydroxy-4-methyl coumarin (4-methyl umbelliferone) has resulted in 4-methyl-7-(4'-phenylphenacyloxy)-benzo [1,2-b] pyran-2-one 3. Reaction of 3 with phosphorusoxychloride in carbon tetrachloride gives a cyclized product 2H-4-methyl-9-(p-phenyl-phenyl)-furo-[2',3',5,6]-benzo[1,2-b]pyran-2-one 4, which on treatment with aromatic aldehydes yields 2H-4-styryl-9-[p-phenyl-phenyl)-furo-[2',3',5,6]-benzo-[1,2-b] pyran-2-ones 5. Compounds 5 are evaluated for their antiviral activity against Japanese encephalitis virus (JEV) and Herpes simplex virus type-I (HSV-I).