I. Tyurenkov, A. Ozerov, E. A. Solodunova
Aug 1, 2013
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Journal
Pharmaceutical Chemistry Journal
Abstract
A series of new quinazoline acetanilide derivatives were synthesized by direct alkylation of quinazoline-4(3H)-one with α-chlorocarboxylic acid anilides. The anxiosedative and antidepressant properties of 10 original derivatives of α-[4-oxoquinazolin-3(4H)-yl]carboxylic acids were studied. It was established that N-(4-methoxyphenyl)-2-[4-oxo-3(4H)-quinazoline]acetamide and 3-[2-oxo-2-(4-phenyl-1-piperazinyl)-ethyl]quinazoline-4(3H)-one exhibited pronounced anxiolytic, antiphobic, and antidepressant activity and were promising candidates for further studies of their psychotropic properties.