T. Duelfer, D. Gala
Jun 1, 1991
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Influential Citations
2
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
A new, short synthesis of 1-(1,2-dihydro-4-hydroxy-1-phenyl-2-oxo-1,8-naphthyridin-3-yl)-pyrrolidinium hydroxide, inner salt, 1, was achieved by condensing methyl 2-phenylamino-3-pyridine carboxylate 2 with ethyl 1-pyrrolidine acetate 4. This gave highly pure product in 60% yield. This synthesis was applied to the preparation of 14C labelled 1. Radiolabelled 1 was synthesized from u-[14C]-aniline in three steps at 97% radiochemical purity and 27.3% radiochemical yield.