A. Pons, T. Poisson, X. Pannecoucke
Aug 16, 2016
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Influential Citations
32
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Journal
Synthesis
Abstract
Abstract The combination of a fluorine atom and a cyclopropane ring, which both possess unique structural and chemical features, can generate new relevant scaffolds with potential interest for the synthesis of new bioactive compounds. In this review, we report the impressive progress recently devoted to the synthesis of fluorocyclopropanes especially using asymmetric methods and highlight some recent reported applications. 1 Introduction 2 Addition of Carbenes to Fluoroalkenes 3 Addition of Fluorocarbenes to Alkenes 4 Michael Initiated Ring Closure 5 Nucleophilic Fluorination 6 Applications to the Synthesis of Biorelevant Compounds 7 Conclusion