Hang Dao Thi, B. Danneels, T. Desmet
Dec 1, 2016
Citations
0
Influential Citations
11
Citations
Journal
Asian Journal of Organic Chemistry
Abstract
3-Methylene-4-(trifluoromethyl)azetidin-2-ones were efficiently prepared from the corresponding 3-oxo-4-trifluoromethyl--lactams and successfully evaluated as novel building blocks in organic synthesis. In particular, Michael additions, electrophilic additions, and cycloadditions were applied to allow easy access to a broad variety of stereodefined mono- and spirocyclic 4-CF3-beta-lactams as useful synthetic intermediates en route to a variety of biologically relevant CF3-functionalized target structures.