L. Hongbin, T. Hui, Yang Dan
2011
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Journal
Chinese Journal of Pharmaceuticals
Abstract
5-Acetylthiophene-2-carboxylic acid obtained through five-step reactions from thiophene was reacted with thionyl chloride and ammonia to give 5-acetylthiophene-2-formamide,then the latter was reacted with bromine and ammonium dithiocarbamate to produce 5-(2-mercapto-4-thiazolyl)-2-thiophene formamide,which reacted successively with epichlorohydrin,tert-butylamine and concentrated hydrochrolic acid to gain arotinolol hydrochloride with an overall yield of about 6%.