Tayebe Asghari, M. Bakavoli, H. Eshghi
Mar 1, 2016
Citations
0
Influential Citations
3
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Several new derivatives of 5,5′-(ethane-1,2-diyl)bis(3-((5-bromo-6-methyl-2-tertiaryamino pyrimidin-4-yl)thio)-4H-1,2,4-triazol-4-amine) () and their novel cyclized products, 1,2-bis(pyrimido[5,4-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)ethane () were synthesized and evaluated as potential inhibitors of 15-lipoxygenase (15-LO). The compounds (1-methylpiperazine) and (1-ethylpiperazine) showed the best IC50 of 15-LO inhibition (IC50 = 4.15 and 2.9 μM, respectively).