D. Ashok, A. Ganesh, S. Ravi
Dec 17, 2014
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Journal
Russian Journal of General Chemistry
Abstract
One pot multicomponent synthesis of 3′,5-Diaryl-1′-phenyl-3,4-dihydro-1′H,2H-3,4′-bipyrazoles from 1-(1-methoxynaphthalen-2-yl)ethanone/1-(2-methoxynaphthalen-1-yl)ethanone, 3-aryl-1-phenyl-1Hpyrazole-4-carbaldehyde and hydrazines in the presence of basic alumina under conventional heating, ultrasound and microwave irradiation methods is presented. All newly synthesized compounds were evaluated for their in vitro antibacterial activity against bacterial strains Gram-positive (Staphylococcus aureus), Gramnegative (Escherichia coli) and strains (Aspergillus niger and Candida metapsilosis). The results of antibacterial and antifungal studies revealed that all compounds exhibited good antimicrobial activity. All synthesized analogues were characterized by IR, 1H and 13C NMR, and mass spectral data and elemental analysis.