Alina Tirla, Moritz E Hansen, Pablo Rivera‐Fuentes
Dec 8, 2017
Citations
0
Influential Citations
6
Citations
Journal
Synlett
Abstract
Abstract Cyclic disulfides, such as asparagusic acid, enhance the uptake of a variety of cargoes into live cells. Here, we report a robust and scalable synthesis of an asparagusic acid modified lysine. This amino acid can be used in solid-phase peptide synthesis. We confirmed that incorporation of this building block into the sequence of a peptide increases its cellular uptake substantially.