Piotr Pomarański, Sauvik Samanta, P. Roszkowski
Oct 19, 2016
Citations
0
Influential Citations
10
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A simple method is reported for the synthesis of chiral mono-naphthyl substituted pyridine derivatives in good yield and with good enantiomeric excess via the asymmetric Suzuki–Miyaura cross-coupling reaction of 3,5-dibromo-4-alkoxy-2,6-dimethylpyridine and naphthalen-1-ylboronic acid. The structure and absolute stereochemistry of 3-bromo-4-methoxy-2,6-dimethyl-5-(naphthalen-1-yl)pyridine were established by single-crystal X-ray analysis.