T. Farghaly, Zeinab A. Abdallah
Feb 2, 2009
Citations
0
Influential Citations
41
Citations
Journal
Arkivoc
Abstract
A series of new N-(3-ethoxycarbonyl-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-2-aryl hydrazono-3oxobutanamide derivatives 4a-i were synthesized and the acid dissociation constants (pKas) for the series prepared were determined and correlated by the Hammett-type equation using the enhanced substituent constants σx. The results of such correlation together with the spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. Some of these derivatives exhibit high antitumor activity.