D. Qi-hua, Z. Hong, Hu Wencai
Mar 18, 2020
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Abstract
trans-3(S)-Amino-4-methyl-2-oxoazetidine-1-sulfonic acid was amided with the activated thioester of ceftazidime side chain and deprotection to afford α-form aztreonam,which after dissolution in ethanol,decolorization and fi ltration,seeded with β-form aztreonam and stirred for 7h at 5-10 ℃ to give β-form aztreonam with 99.5% purity and 0.3% residual ethanol.