Yu Xinhong
2010
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Baclofen hydrochloride,an antispastic agent,was synthesized from 4-chlorobenzaldehyde and malonic acid by Knoevenagel-Doebner condensation and esterification to give methyl 3-(4-chlorophenyl) acrylate,which was subjected to Michael addition,hydrolysis,catalytic hydrogenation and then salt formation with an overall yield of about 52%.