Xu Bei-hu
2014
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Guangzhou Chemical Industry
Abstract
To study baicalein derivatives and their biological activity,it was necessary to investigate the synthesis of the compounds. Phloroglucinol was reacted with acetonitrile by the Hoesch reaction,reaching to trihydroxyacetophenone( 3).( 3) was condensated with benzoyl acetate,obtaining the cyclization product( 7),which was oxidized by H2O2to give the final product( 8). The raw materials were readily available by this method,and a relatively high yield was obtained,by the comparatively short synthetic route,without the protection of the phenolic hydroxyl group. This method was suitable for laboratory preparation of baicalein.