Feng Bai-cheng
2008
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Journal
Journal of Qingdao University of Science and Technology
Abstract
4-Nitro-N-[3-(2-hydroxyethyl)sulfonyl]phenylbenzoylamide was synthesized using 3-(2-hydroxyethylsulfonyl)aniline and 4-nitrobenzoic acid as starting materials through acyl chlorination and condensation.The effects of catalyst,halogenating agent on acyl chlorination results were studied.The results showed that DMF and thionyl chloride were suitable catalyst and halogenating agent respectively,the yield of acyl chlorination was 97%.And the obtained optimum conditions of condensation were n(3-(2-hydroxyethylsulfonyl) aniline)∶n(4-nitrobenzoic acid)=1.2∶1,reaction temperature 30 ℃,reaction time 2 h.Under above conditions,the yield was 90%.The structures of product and intermediate were characterized by IR and 1H NMR.