M. Balazs, C. A. Anderson, R. Iwamoto
Apr 1, 1970
Citations
0
Influential Citations
10
Citations
Journal
Journal of pharmaceutical sciences
Abstract
The synthesis of 4-{p-[(2-chloroethyl)-(2-hydroxyethyl)-amino]phenyl}butyric acid is reported. Investigation of the behavior of this compound in the NBP assay procedure showed that it alkylates NBP in a manner similar to chlorambucil. Therefore the results obtained from the assay of chlorambucil and similar aryl nitrogen mustards by the NBP method must be interpreted with due caution.