Zhou Bang-chan
2014
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Journal
Drugs and Clinic
Abstract
Objective To design and synthesize 4-(2′,3′-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate. Methods 2,3-Dichlorobenzaldehyde was used as starting material to synthesize the target compound by condensation, cyclization, and hydrolysis reactions. Results The target compound was synthesized and characterized by MS and 1H-NMR. And the purity detected by HPLC was 98.3%. Conclusion The synthesis of 4-(2′,3′-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate provides convenience for the study of impurities in clevidipine butyrate.