E. H. Banitt, G. J. Conard
May 1, 1981
Citations
0
Influential Citations
6
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
N-(2-Piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide acetate (flecainide acetate; R-818), a new antiarrhythmic agent, was labelled with carbon-14 at the carboxamide position for metabolic studies. A three-step synthetic route starting from 2,5-dihydroxybenzoic acid-carboxyl-14C provided chemically pure flecainide-14C acetate in 37.0% overall yield. Thin layer chromatographic analysis indicated that the carbon-14 labelled product (12.28 mCi/mmol) was at least 99.5% radiochemically pure.