Song Dan-qing
2007
Citations
0
Influential Citations
1
Citations
Journal
Chinese Journal of New Drugs
Abstract
Objective: To synthesize bendamustine.Methods: The target compound was synthesized from 2,4-dinitro-chlorobenzen as a starting material via nine steps including substitution,reduction,acylation,cyclization,reduction,substitution,hydrolization and salification.Results: The structure of the target compound was confirmed by MS,1H-NMR,IR analysis.The total yield of bendamustine was 33.5%.Conclusion: This cost-saving and simplified method can be used in the industrial manufacture.