Aïda R. Nadji-Boukrouche, Sopheak On, O. Khoumeri
Apr 22, 2015
Citations
0
Influential Citations
6
Citations
Journal
Tetrahedron Letters
Abstract
A new series of 1-methyl-1H-benzo[f]indole-4,9-dione derivatives was prepared via a one-pot ‘Sonogashira-Cyclization’ reaction with propagylic alcohol in the presence of a palladium catalyst leading to regio-isomers of 2- and 3-(chloromethyl)-1-methyl-1H-benzo[f]indole-4,9-dione after chlorination. The reaction of the 2- and 3-(chloromethyl)-1-methyl-1H-benzo[f]indole-4,9-dione derivatives with various aldehydes and N-sulfonimides in the presence of TDAE under mild conditions led to the corresponding alcohols and N-sulfonamide derivatives in good yield.