S. A. Hutchinson, Henning Luetjens, P. Scammells
Dec 16, 1997
Citations
0
Influential Citations
18
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
5-(3-Hydroxypropyl)-7-methoxy-2-(3′-methoxy-4′-hydroxyphenyl)benzo[b]furan-3-carbaldehyde (XH-14, 1) has been reported to be a potent A1 adenosine antagonist. We have developed an efficient synthesis of this compound that should prove valuable for further structure-activity studies. The synthesis incorporates optimised methodology for the selective protection of a hydroxyl group and the ortho-bromination of a phenol.