K. Joseph, Isabel Larraza-Sanchez
Jan 5, 2011
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A series of benzyl bromides were efficiently prepared from the corresponding alcohols with Br 3 CCOCBr 3 /PPh 3 at low temperatures and under neutral conditions. The present protocol was applied to the heterocyclic analogues and to the successful synthesis of the precursor of the antiulcer drug omeprazole, thus furnishing an alternate, mild method for the preparation of these drug intermediates. A significant steric factor was observed throughout both series supporting a S N 2 mechanism.