Wang Junfang
2012
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Benzyl trans-octahydro-1H-indole-2-carboxylate hydrochloride,the key intermediate of trandolapril,was synthesized from cyclohexanone and acrylonitrile by Micheal addition and cyclization to give 3,4,5,6,7,8-hexyhydroquinolin-2-one,which was subjected to reduction with formic acid and sodium formate,chlorination,mono-dechlorination,rearrangement,benzylation,chiral separation and salt formation.Four trans-optical isomers of the target compound were obtained.