Lan Zhi-yin
2004
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Journal
Journal of Chongqing Three-gorges University
Abstract
OBJECTIVE: To synthesize 1-benzyl-4-[(5,6-dimethoxy-l-indanon) -2-yl] methylpiperidine hydrochloride (I)and improve the synthetic method. MEHTOD: 1-benzyl- 4- [(5,6- dimethoxy-l- indanon)- 2-yl] methylpiperidine hydrochloride(Ⅰ) was synthesized by several steps of Adole condensation,reduction, salt from 1-benzyl-4-piperidine-carboaldehyde and 5,6-Dimethoxy-1-indanone RESULTS: The total yield was above 60%. The chemical structure of synthetic product was conformed by melting point and IR.CONCLUSION: This synthetic technique is simple and easy to produce on industrial scale.