Xiao-Le Tao
2003
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
Bicalutamide was synthesized from methyl methacrylate via oxidation, condensation with 4 fluorothiophenol and hydrolysis to give α hydroxy acid which was first reacted with 2 trifluoromethyl 4 aminobenzonitrile and then oxidized with m chloroperoxybenzoic acid. The overall yield was about 11.2%.