Cao, Xiao, Joullié
Oct 22, 1999
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0
Influential Citations
8
Citations
Journal
Organic letters
Abstract
Cyclopropylamines and substituted cyclopropylamines are important building blocks or substituents in a variety of biologically active compounds. Here, we report the facile syntheses of cyclopropylamines by Ti(II)-mediated intramolecular coupling of a terminal olefinic moiety and the N,N-dimethylcarboxamide moiety of amino acid derivatives. The products have novel and strained bicyclic structures. The yields were good (78−83%) for all three substrates with diastereomeric ratios of about 3:1.