S. Collier, Xiang Wu, Z. Poh
Mar 30, 2011
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0
Influential Citations
9
Citations
Journal
Synthetic Communications
Abstract
Abstract A new and efficient synthesis of the non-sedating histamine H1 receptor antagonist Bilastine is reported. The new route employs a convergent strategy, with a longest linear sequence of five steps, giving slightly improved yields over the previous routes. The use of anhydrous metal-halogen exchange, hazardous ethylene oxide, and a tedious protection of the carboxylic acid function are all avoided.