T. R. R. Naik, H. Naik, H. R. P. Naik
Aug 31, 2009
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Medicinal chemistry (Shariqah (United Arab Emirates))
Abstract
The synthesis and docking studies of novel benzo[b][1,8]naphthyridines is discribed. The docking studies show that the derivatives prefer to bind the AT-rich region of double stranded DNA (ds-DNA). The maximum binding energy -7.16 (kcal/mol) was observed for benzo[b][1,8]naphthyridine-5-thiol 5a and it is a better candidate as an enantioselective binder to ds-DNA than the other derivatives of benzo[b][1,8]naphthyridines. When photoirradiated at 365 nm, benzo[1,8]-naphthyridines have been found to promote the photocleavage of plasmid pUC19 DNA.