Z. Yi
2001
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0
Influential Citations
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Journal
Chinese Journal of Applied Chemistry
Abstract
Pyridazinone-carbamate derivatives 5a~5lwere synthesized starting from 2-substituted-4,5-dichloro pyridazinones 1via two routes. One is that 2-substituted-4-chloro-5-hydroxyl pyrida-zinones 2reacted with β-bromoethyl carbamates to afford compounds 5a and 5b. The other is that 2-substituted-4-chloro-5-(2-amino ethyloxyl)pyridazinones 3obtained from the reaction of 1with amino ethanol, reacted with chloroformate to give 5a~5l. Furthermore, the catalytic hydrogenation of 3gave 2-substituted-5-(2-amino ethyloxyl)pyridazinones 4, which reacted with chloromates to produce compounds 6a~6dat temperatures between -10~-5 ℃, and to N,N-dicarbamates 7a and 7bat 0~15 ℃. The reactivity of intermidiates 3 and 4was also discussed. The preliminary bioassay indicated that almost all of the compounds showed fungicidal activities.