Dic Finechemicals
2007
Citations
0
Influential Citations
3
Citations
Journal
Chinese Journal of Organic Chemistry
Abstract
Ethyl 3-aryl-1H-pyrazole-5-carboxylate reacted with arylmethyl chloride in acetone or acetoni-trile in the presence of potassium carbonate to afford 1-arylmethyl-3-aryl-1H-pyrazole-5-carboxylate deriva-tives in good yields. The substituent on aryl moiety and solvent can influence on the yields of the reactions. The structures of all products were confirmed by 1H NMR, 13C NMR, IR and MS spectra. The structure of compound 3c was determined by X-ray single crystal diffraction method. The compounds 3a~3d promoted HUVEC apoptosis at the concentrations of 5~20 μmol?L-1 to a certain extent and the effect on the cell vi-ability was dose-dependent.