Y. Li, Li Liu, Kun Jin
Mar 1, 2010
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0
Influential Citations
8
Citations
Quality indicators
Journal
Chinese Chemical Letters
Abstract
Abstract A novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized by the condensation of 4-amino-5-[2-(4-chlorophenoxymethylbenzimidazole)-1-methylene]-3-mercapto-1,2,4-triazole with various (un)substituted aromatic acids in the presence of phosphorous oxychloride. These compounds were investigated for their inhibitory activity to E. coli methionine aminopeptidase ( Ec MetAP1). Some of the tested compounds showed significant inhibitory activity.