P. Lavanya, K. V. Vani, K. Vasu
2010
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Journal
Journal of chemical and pharmaceutical research
Abstract
4-Aminopyrimidine-5-carbonitrile (1) underwent faci le condensation with various aromatic acid derivatives in the presence of 1-[3-(dimethylamino) propyl]-3-ethylcarbodiimidehydrochloride (EDC.HCl) and small catalytic amount of TEA afforde d corresponding substituted-N-(5- cyanopyrimidin-4-yl)benzamide derivatives 3a-j. The y were characterized by IR, 1 H, NMR and Mass spectral data. All the compounds were screened for anti-microbial, anti-oxidant activities.