Philippe Auzeloux, J. Papon, Thierry Masnada
Apr 1, 1999
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0
Influential Citations
17
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
N-(2-diethylaminoethyl)-4-iodobenzamide has been reported to be an excellent agent for malignant melanoma diagnosis by SPECT. To obtain a 99mTc analogue, we synthesized a sodium N-{2-[4-(N-diethylaminoethylcarbamoyl)phenyl]ethyl}-N-methyldithiocarbamate ligand in 7 steps from methyl 4-(bromomethyl)benzoate. The corresponding nitridotechnetium complex formed by a ligand exchange method was purified and its biodistribution in mice bearing the B16 murine melanoma was determined. Copyright © 1999 John Wiley & Sons, Ltd.