K. Hatzade, V. Taile, P. Gaidhane
Aug 1, 2008
Citations
1
Influential Citations
12
Citations
Journal
ChemInform
Abstract
The synthesis of a number of 7-hydroxy-3-pyrazolyl-chromen-4H-ones and their O-glucosides has been described. 7Hydoxy-3-formyl chromen-4H-one 1 on condensation with substituted acetophenones in the presence of piperidine in dry alcohol affords 7-hydroxy-3-(3-oxo-3-arylprop-1-enyl)-4H-chromen-4-ones 2 which on cyclization with phenyl hydrazine hydrochloride leads to the formation of 7-hydroxy-3-(1-phenyl-3-aryl-1H-pyrazol-5-yl)-4H-chromen-4-ones 3. 7-O-β-DGlucopyranosyloxy-3-(1-phenyl-3-aryl-1H-pyrazol-5-yl)-4H-chromen-4-ones 5 have been synthesized by the reaction of 2, 3, 4, 6-tetra-O-acetyl-α-D-glucopyranosyl bromide with potassium salt of 3 followed by deacetylation with Zn(CH3COO)2 in absolute methanol. Some of the newly synthesized compounds have been screened for their antimicrobial and antioxidant activity.