Z. Xia
2015
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Chinese Journal of Synthetic Chemistry
Abstract
Fifteen novel 1,3,4-thiadiazole amide compounds containing piperazine were synthesized using aminothiourea and carbon disulfide as the starting materials. The structures were characterized by1 H NMR,13 C NMR,IR,ESI-MS and elemental analysis. The bioassay results indicated that N-{ 5-[( 2,4-dichlorobenzyl) thio]-1,3,4-thiadiazol-2-yl}-2-( 4-methylpiperazin-1-yl) acetamide( 6b)and N-【5-{ [4-( trifluoromethoxy) benzyl]thio }-1,3,4-thiadiazol-2-yl 】-2-( 4-methylpiperazin-1-yl)acetamide( 6e) demonstrated inhibitory effects on Xan-thomonas campestris pv. oryzae with EC50of17. 5 μg·m L-1and 19. 8 μg · m L-1,respectively. N-{ 5-[( 3-methylbenzyl) thio]-1,3,4-thiadiazol-2-yl}-2-( piperazin-1-yl) acetamide( 6k) showed certain antiviral activity against tobacco mosaic virus at 500 μg·m L-1.