Shivraj G Hunasnalkar, S. Gazi, S. Patil
Jun 28, 2010
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Influential Citations
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Journal
Asian Journal of Research in Chemistry
Abstract
Substituted benzothiazoles have received considerable attention during last two decades as they are endowed with variety of biological activities and have wide range of therapeutic properties. A Literature survey indicates that benzothiazole derivatives possess different pharmacological and biological activities; which of most potent activity are anti-inflammatory and anti-bacterial activity. The starting product is 6-substituted-1, 3-benzothiazol-2-amine was prepared from 4-substituted anilines and potassium thiocyanate in one step. Substituted Benzothiazolyl-2-amines were reacted with chloroacetyl chloride to yield 2-chloro acetyl amino-6-substitued benzothiazoles, which were reacted with 2-mercaptobenzothiazole and 2-hydrazinobenzthiazole gave 2-(1,3-benzothiazol-2-yl thio)-N-(6-substitued-1,3-benzothiazol-2-yl) acetamides and 2-[2-(1,3-benzothiazol-2-yl)hydrazino]-N-(6-methyl-1,3-benzothiazol-2-yl) acetamides respectively. The synthesized compounds were characterized by elemental analysis and spectral data.