M. Bretner, M. Balińska, K. Krawiec
May 1, 1995
Citations
0
Influential Citations
11
Citations
Journal
Nucleosides, Nucleotides & Nucleic Acids
Abstract
Abstract Two pathways are described for the synthesis of the 2′-deoxynucleosides of 2-thiocytosine and 5-fluoro-2-thiocytosine: (a) by nucleoside condensation, (b) by amination of the corresponding nucleosides of 2,4-dithiouracil. Biological activities vs two cell systems are described. The nucleosides are moderate to weak substrates of deoxycytidine kinase and, partly as a result of this, reasonable good inhibitors of the enzyme