W. M. Al-Adiwish, F. A. Shtewi, Munira Muftah Ashrif
2017
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Abstract
5-Amino-3-(4-chlorophenylamino)-1 H -pyrazole-4-carbonitrile 3 was prepared in high yield from the reaction of hydrazine hydrate with known 2-[(4-chlorophenylamino)(methylthio)methylene]malononitrile 2a (which was prepared from reaction of 2-[bis(methylthio)methylene]malononitrile 1 with p -Chloroaniline) under reflux in ethanol. The compound 3 was utilized as a key intermediate for the synthesis of pyrazolo[1, 5- a ]pyrimidines 4a-b, 5a-c and 6 by reactions with some of ketene- S , S -and N , S -acetals. The antibacterial and antifungal activities, as well cytotoxicity against Breast cancer cells (MCF7) of some selected compounds are also reported.